CD8+ T cells in Hashimoto’s thyroiditis-associated papillary thyroid carcinoma
Authors' conclusion
Overall, CD8+ T cells in HT-PTC exhibited no pronounced exhaustion-associated feature pattern and retained functional activity.
Study context
- Population
- Papillary thyroid carcinoma (PTC) with or without Hashimoto's thyroiditis (HT); TCGA data and surgically resected specimens from a single centre
- Comparison
- HT-PTC vs non-HT-PTC
- Outcome
- CD8+ T cell features in HT-PTC
Methodological detailstranscriptomic analysis with experimental validation, TCGA data, surgically resected specimens
- Transcriptomic analysis with experimental validation
- TCGA data
- Surgically resected specimens
Main finding
As reported in the abstract
- Increased CD8+ T cell infiltration in HT-PTC vs non-HT-PTC (TCGA data)
- Tumor-derived CD8+ T cells maintained cytokine secretion capacity
- Lower expression of TIM-3 and LAG-3, with higher Granzyme B levels
- In coculture, associated with reduced proliferation and migration of thyroid cancer cells
- No pronounced exhaustion-associated feature pattern; retained functional activity
Original publication
CD8+ T cells in Hashimoto’s thyroiditis-associated papillary thyroid carcinoma. Eur Thyroid J. Published 6 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →