Association Between Gross Features and Coexistence of BRAF V600E and TERT Promoter Mutations in Papillary Thyroid Carcinomas: A Combined Analysis Incorporating Clinicopathologic Features
Authors' conclusion
The BRAFV600E and TERT-p double mutation in PTC was significantly associated with relatively old age, larger tumor size, lobulated configuration in tumor margin, papillary excrescences on the cut surface, solid-cut surface, ETE, and high Ki-67 LI.
Study context
- Population
- Patients with papillary thyroid carcinoma (PTC) surgically resected January 2018–October 2023 at a single institution
- Participants
- 375 patients
- Exposure
- PTC with vs without BRAFV600E and telomere reverse transcriptase promoter (TERT-p) double mutation
- Double mutationn = 78
- Outcome
- Association of clinicopathologic features, including macroscopic features, with coexistent BRAFV600E and TERT-p mutations
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Factors associated with the double mutation (multivariable analysis)
- Older age (≥55 years), OR
- 12.083 (4.498-32.456) (95% CI)
- Tumor size >2.0 cm, OR
- 2.722 (1.104-6.712) (CI)
- Lobulated tumor margins, OR
- 16.114 (3.155-82.296) (CI)
- Papillary excrescences on cut surface, OR
- 17.573 (3.462-89.201) (CI)
- Solid-cut surface, OR
- 4.012 (1.084-14.849) (CI)
- Minimal extrathyroidal extension (ETE), OR
- 4.156 (1.209-14.282) (CI)
- Gross ETE, OR
- 6.517 (1.734-24.490) (CI)
- Ki-67 labeling index (LI) ≥5%, OR
- 12.145 (4.354-33.877) (CI)
Observational data: associations, not effects.
Further findings
Prevalence of BRAFV600E and TERT-p double mutation
- Double mutation identified
- 78 (20.8%)
Disease-free survival (DFS)
- Double mutation significantly correlated with shorter DFS
Original publication
Association Between Gross Features and Coexistence of BRAF V600E and TERT Promoter Mutations in Papillary Thyroid Carcinomas: A Combined Analysis Incorporating Clinicopathologic Features. Thyroid. Published 31 October 2024. doi:10.
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