Determinants of Health-Related Quality of Life in Differentiated and Poorly Differentiated Thyroid Cancer Patients With Structural Incomplete Response: A Multicenter Cross-Sectional Study
Authors' conclusion
Despite the absence of a longitudinal design and internal control group, this study emphasizes the importance of systematically assessing HRQOL in DTC/PDTC patients with SIR and highlights the interplay between psychosocial factors and functional status in shaping patient-reported outcomes.
Study context
- Population
- Adults with cytologically or histologically confirmed DTC/PDTC and structural incomplete response (SIR)
- Participants
- 148 adults
- Outcome
- Determinants of HRQOL (EORTC QLQ-C30, QLQ-THY34, Hospital Anxiety and Depression Scale)
Methodological detailsprospective, multicenter
- Prospective
- Multicenter
Main finding
As reported in the abstract
Determinants of HRQOL
- SIR patients reported significantly reduced health-related quality of life (HRQOL) vs disease-free survivors, particularly fatigue, sleep disturbance, concern for others, exhaustion and joint pain
- Neither disease management strategy (active surveillance vs tyrosine kinase inhibitor or other treatments) nor disease status (stable vs progressive) significantly predicted overall HRQOL
- Lower physical functioning, female gender and higher emotional distress independently associated with poorer HRQOL
- Gender-related differences emerged only among patients with preserved physical functioning
Observational data: associations, not effects.
Original publication
Determinants of Health-Related Quality of Life in Differentiated and Poorly Differentiated Thyroid Cancer Patients With Structural Incomplete Response: A Multicenter Cross-Sectional Study. Endocr Pract. Published 2 April 2026. doi:10.
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