Incidentally vs non-incidentally diagnosed papillary thyroid carcinoma: are there differences?
Authors' conclusion
ITC patients were older and had smaller tumours. NITC showed no worst histological features or 5-year clinical outcome. Approximately, one third of ITC had diameters >20mm. As even large tumours can be ITC, overdiagnosis can be the most likely cause for the TC increasing incidence.
Study context
- Population
- Papillary TC (PTC) cases that completed a 5-year follow-up
- Participants
- 225 participants
- Exposure
- Incidental vs non-incidental PTC
- ITCn = 122
- Outcome
- Demographic, clinical, histological data and clinical outcomes
- Follow-up
- 5 years
Main finding
As reported in the abstract
5-year clinical outcome
- No differences in the rates of persistence of disease
- Logistic regression: diagnostic modality had no impact on the 5-year clinical outcome
Observational data: associations, not effects.
Further findings
Tumours >20mm
| Outcome | ITC | NITC | P value |
|---|---|---|---|
| Women | 95 events | 78 events | |
| AgeITC significantly older | 53.3 ± 14.8 | 47.2 ± 17.7 | P = 0.006 |
| Tumour sizeSmaller in ITC | mean 19.1 ± 9.2 | mean 28.6 ± 16.2 | P < 0.01 |
- pTNM staging · higher prevalence of T3a and T4 in NITC
- P < 0.01
- pTNM staging · higher M1 status in NITC
- P = 0.025
Family history, histology and RAI
- No differences in family history of thyroid carcinoma (TC)
- No differences in multifocality, histological thyroiditis, aggressive PTC subtypes, capsule or lymph-vascular invasion and gross extrathyroidal extension
- No differences in number of patients submitted to RAI or RAI activity
Original publication
Incidentally vs non-incidentally diagnosed papillary thyroid carcinoma: are there differences? Eur Thyroid J. Published 25 July 2024. doi:10.
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