Nuclear STAT3 expression is associated with favorable prognosis in papillary thyroid carcinoma
Authors' conclusion
n-STAT3 scores in cases with PTC were associated with favorable prognosis. Further studies are required to elucidate the mechanism.
Study context
- Population
- PTC cases with M0 diagnosed between 1993 and 20121,132 PTC cases included
- Participants
- 764 vs 371
- Exposure
- High vs low nuclear STAT3 H-score
- High n-STAT3n = 764
- Low n-STAT3n = 371reference
- Outcome
- RFS by n-STAT3 score
Methodological detailsimmunohistochemical staining with anti-STAT3 antibody
- Immunohistochemical staining with anti-STAT3 antibody
Main finding
As reported in the abstract
RFS
10-year RFS
20-year RFS
- High n-STAT3 vs Low n-STAT3: P < 0.0001 — significantly better recurrence-free survival (RFS) with high n-STAT3
Observational data: associations, not effects.
Further findings
n-STAT3 score
- Median n-STAT3 score
- 105
Factors associated with poor RFS
- Age (≥55 years), tumor size (≥4 cm), extrathyroidal extension, larger maximum lymph node size (≥30 mm) and low n-STAT3 associated with poor RFS on univariate and multivariate analyses
Original publication
Nuclear STAT3 expression is associated with favorable prognosis in papillary thyroid carcinoma. Eur Thyroid J. Published 17 October 2025. doi:10.
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