Molecular Profiles of Noninvasive, Minimally Invasive, and Invasive Follicular Patterned Thyroid Neoplasms with Papillary Nuclear Features
Authors' conclusion
While follicular patterned lesions with papillary nuclear features overall tend to display RAS-like alterations, EFVPTC cases, followed by iFVPTC in this series, showed increasing proportions of more aggressive drivers. EFVPTC and NIFTP show much molecular overlap, with predominance of RAS-like alterations, suggesting that these tumors are part of a genetic continuum, while still ranked differentially.
Study context
- Population
- Cases with histological NIFTP, encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) or infiltrative follicular variant of papillary thyroid carcinoma (iFVPTC) with ThyroSeq test results
- Exposure
- Molecular profiles of NIFTP vs EFVPTC vs iFVPTC
- Outcome
- Intermediate and aggressive drivers
Main finding
As reported in the abstract
EFVPTC vs NIFTP: P = 0.0068 · iFVPTC vs EFVPTC: P = 0.0158 · iFVPTC vs NIFTP: P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | NIFTP | EFVPTC |
|---|---|---|
| RAS-like alterations | 100% | 75% |
| RAS-like GEAs | 55.2% | 47.2% |
RAS-like gene expression alterations (GEAs)
- No significant difference in GEAs among the three histological groups
Copy number alterations (CNAs)
- Many NIFTP and EFVPTC cases showed CNAs with 22q-loss
Original publication
Molecular Profiles of Noninvasive, Minimally Invasive, and Invasive Follicular Patterned Thyroid Neoplasms with Papillary Nuclear Features. Thyroid. Published 3 May 2023. doi:10.
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