Endocrine oncology

Investigation of pre‐operative demographic, biochemical, sonographic and cytopathological findings in low‐risk thyroid neoplasms

Clin Endocrinol (Oxf)Published Retrospective cohort study

Authors' conclusion

The majority of LRTNs were NIFTPs in our population and all WDT-UMPs were solitary lesions. Index nodule volume was the most essential discriminating sonographic finding but further research must be performed before discriminatory potential can be described.

Study context

Population
Cases diagnosed with low-risk thyroid neoplasms (LRTNs) from histopathology of 2453 malignant thyroidsof 2453 malignant thyroids
Participants
99 cases
Exposure
Four subgroups of low-risk thyroid neoplasms: Well-differentiated carcinoma-not otherwise specified (WDC-NOS), NIFTP, well-differentiated tumours of uncertain malignant potential (WDT-UMP) and follicular tumour of uncertain malignant potential (FT-UMP)
Outcome
Pre-operative demographic, biochemical, sonographic and cytopathological characteristics of LRTN subgroups

Main finding

As reported in the abstract

NIFTPs share of all LRTNs
69.7%
WDT-UMPs with solitary nodules
100%
Index nodule volume differed among groups
p = .036
Index nodule volume lowest in WDC-NOS
0.68 (0.63-0.72 cc)
Index nodule volume highest in FT-UMP
12.6 (0.5-64 cc)
Index nodule TIRADS differed among groups
p = .021

Observational data: associations, not effects.

Original publication

Investigation of pre‐operative demographic, biochemical, sonographic and cytopathological findings in low‐risk thyroid neoplasms. Clin Endocrinol (Oxf). Published 14 September 2023. doi:10.1111/cen.14965

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