Anthropometric, dietary, and lifestyle factors and risk of advanced thyroid cancer: The NIH‐AARP diet and health cohort study
Authors' conclusion
Our findings suggest that greater waist circumference and adulthood weight gain are associated with thyroid cancers at higher risk for recurrence. These results may have implications for the primary prevention of advanced thyroid cancer.
Study context
- Population
- National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study participants without a history of cancer who completed a mailed questionnaire in 1996–1997, followed through 2011 via state cancer registries (US)124,656 women · 179,466 men
- Participants
- 304,122 participants
- Exposure
- Anthropometric, dietary and lifestyle factors in relation to high-risk (high-risk thyroid cancer (HRTC)) vs low-risk thyroid cancer (LRTC)
- Outcome
- Risk of HRTC and, separately, LRTC, defined using guidance from the ATA initial risk of recurrence classification
- Follow-up
- Median 10.1 years
Methodological detailsmultivariable-adjusted Cox proportional hazards regression
- Multivariable-adjusted Cox proportional hazards regression
Main finding
As reported in the abstract
- Diagnosed with thyroid cancer
- 426 (HRTC n = 95; LRTC n = 331)
- Waist circumference (per 5 cm), HRTC: HR
- 1.13 (1.01-1.27) (95% CI)
- Weight gain from age 18 y to baseline (per 5 kg), HRTC: HR
- 1.14 (1.02-1.28) (95% CI)
- Vegetable intake (per cup equivalents/day), LRTC: HR
- 1.15 (1.01-1.30) (95% CI)
- Current vs never cigarette smoking, LRTC: HR
- 0.39 (0.23-0.68) (95% CI)
- Alcohol (per drink/day), LRTC: HR
- 0.83 (0.70-0.97) (95% CI)
Observational data: associations, not effects.
Further findings
Sex-specific associations with LRTC
- Association of LRTC with vegetable intake limited to men; association with current smoking more pronounced in women
Original publication
Anthropometric, dietary, and lifestyle factors and risk of advanced thyroid cancer: The NIH‐AARP diet and health cohort study. Clin Endocrinol (Oxf). Published 11 September 2023. doi:10.
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