Cytological and Ultrasound Features of Thyroid Nodules Correlate With Histotypes and Variants of Thyroid Carcinoma
Authors' conclusion
At cytology, most FTC, NIFT-P, FV-PTC, and SV-PTC were indeterminate, most CV-PTC and TCV-PTC were suspicious for malignancy or malignant. Ultrasound can be helpful in ruling out TCV-PTC.
Study context
- Population
- Patients with thyroid nodule(s) who underwent thyroidectomy, Endocrinology Unit, University Hospital of Pisa; histology correlated with FNA categories (Italian TIR1–TIR5) and US features1,117 patients (groups count tumors)
- Participants
- 1,018 / 249 / 167 / 49 / 34 / 15 / 52 / 50 / 11 / 3
- Exposure
- Cytological and US features across thyroid carcinoma histotypes and papillary thyroid carcinoma (PTC) variants
- Benignn = 1,018
- CV-PTCn = 249
- FV-PTCn = 167
- TCV-PTCn = 49
- SV-PTCn = 34
- Other PTC variantsn = 15
- NIFT-Pn = 52
- Follicular thyroid carcinoma (FTC)n = 50
- Poorly differentiated thyroid carcinoma (PDTC)n = 11
- Anaplastic thyroid carcinoma (ATC)n = 3
- Outcome
- Indeterminate cytology (TIR3A or TIR3B) vs suspicious for malignancy or malignant (TIR4 or TIR5)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- PTC with indeterminate cytology (TIR3A or TIR3B)
- 36.3%
- PTC suspicious for malignancy or malignant (TIR4 or TIR5)
- 56.6%
- FTC TIR3A or TIR3B
- 84.0%
- NIFT-P TIR3A or TIR3B
- 69.3%
- FV-PTC TIR3A or TIR3B
- 72.5%
- SV-PTC TIR3A or TIR3B
- 73.6%
- CV-PTC TIR4 or TIR5
- 79.9%
- TCV-PTC TIR4 or TIR5
- 95.9%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| US pattern: hypoechoic, irregular margins and no microcalcificationsTCV-PTC vs CV-PTC · more frequent in TCV-PTC | P = 0.02 |
- US pattern: hypoechoic, irregular margins and no microcalcifications — PPV
- 38.9%
- US pattern: hypoechoic, irregular margins and no microcalcifications — NPV
- 85.5%
Original publication
Cytological and Ultrasound Features of Thyroid Nodules Correlate With Histotypes and Variants of Thyroid Carcinoma. J Clin Endocrinol Metab. Published 2 June 2023. doi:10.
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