Five-Year Follow-Up of Health-Related Quality of Life in Differentiated Thyroid Cancer Patients Treated with Total Thyroidectomy and Radioiodine in Sweden: A Nationwide Prospective Cohort Study
Authors' conclusion
The mental component of HRQOL improves over time following DTC treatment. HRQOL in patients with DTC is not explained by TSH suppression. Although overall differences in physical and mental HRQOL compared with the general population were small 5 years after treatment, several specific psychosocial HRQOL domains were clinically meaningfully reduced.
Study context
- Population
- Patients with differentiated thyroid cancer (DTC) treated with total thyroidectomy and planned for radioiodine, all Swedish hospitals treating DTC, identified 2012–2017487 identified
- Participants
- 351 patients
- Outcome
- Change in HRQOL (SF-36 physical and mental QOL summary measures)
- Follow-up
- At treatment and after 1, 3, and 5 years
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Mental QOL improved on average per year
0.61
p < 0.001
Observational data: associations, not effects.
Further findings
Thyroid-stimulating hormone (TSH) and health-related quality of life (HRQOL)
- TSH levels not predictive of physical or mental QOL, or their change over time
Physical and mental QOL vs Swedish general population · 5 years
- Significant difference in physical QOL vs general population, small effect size (Cohen's d)
- 0.29
- Significant difference in mental QOL vs general population, small effect size (Cohen's d)
- −0.21
SF-36 domains general health, vitality, social functioning, mental health vs general population · 5 years
- Lower than general population; differences clinically significant (difference)
- 8.7-13.3
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →