Clinical Evolution of Sporadic Medullary Thyroid Carcinoma With Biochemical Incomplete Response After Initial Treatment
Authors' conclusion
In sporadic MTC patients with BiR, the risk of detection of structural disease was about 50% at 10 years. Higher bCTN levels and staging predicted the risk of detecting structural disease. According to these findings, stricter follow-up should be reserved for MTC with BiR and elevated values of bCTN and to those with an advanced stage. Long follow-up should be considered for all BiR patients since 50% of them develop structural disease within 10 years.
Study context
- Population
- Patients surgically treated for sporadic medullary thyroid carcinoma (MTC) (2000–2018), followed up at the endocrine unit of the University Hospital of Pisa145 with biochemical incomplete response (BiR)
- Participants
- 599 participants
- Outcome
- Overall and per-site prevalence of structural disease detection in sporadic MTC patients with biochemical incomplete response (BiR)
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
BiR
44.1%
64 events
- Structural disease detected at a single site, mainly cervical lymph nodes
- 73.6%
Observational data: associations, not effects.
Further findings
Classified as BiR after surgery (of 599 patients) · median of 5 months from surgery
- Patients classified as BiR
- 145 of 599 (24.2%)
Structural disease at a single site (prevalently cervical lymph nodes)
- Single-site structural disease
- 73.6%
Predictors of structural disease · first evaluation after surgery
- Only basal calcitonin (bCTN) and stage IVa/b were independent predictive factors
- Structural disease more frequent with shorter CTN doubling time and somatic RET mutation
Original publication
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