Tumor Grade and Molecular Characteristics Associated with Survival in Sporadic Medullary Thyroid Carcinoma
Main finding · DSS by IMTCGS grade (multivariable Cox analysis)Result — go to the resultHazard ratio 8.8 CI 2.7–28.3Authors' conclusion
IMTCGS grading was associated with DSS independently of other clinical, pathological, and molecular factors. Moreover, MTC grading was associated with RET and RAS patterns, which explains, at least in part, the molecular basis of the aggressive behavior of high-grade MTC.
Study context
- Population
- Consecutive sporadic medullary thyroid carcinoma (MTCs) from patients undergoing initial surgery, January 2000–January 2022, Padua Endocrine Surgery Unit
- Participants
- 141 consecutive sporadic MTCs
- Exposure
- High-grade vs low-grade MTC
- High-graden = 32
- Low-graden = 107reference
- Outcome
- DSS by IMTCGS grade (multivariable Cox analysis)
- Follow-up
- Median 80.0 months (IQR 41.5-122.5)
Methodological detailsconsecutive patients, single-centre
- Consecutive patients
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
8.8
CI 2.7–28.3
P = 0.005
High-gradevs Low-grade
HR 8.8 (CI 2.7–28.3); P = 0.005
Observational data: associations, not effects.
Further findings
RET mutation
P < 0.001
RET-M918T mutation
P < 0.001
| Outcome | High-grade | Low-grade |
|---|---|---|
| RAS mutation | 0 events | 11.8% |
MTC-related deaths
- Died from disease-related causes
- 17 (12.1%)
Disease-specific survival (DSS) by RET mutation status
- RET-mutated patients had more aggressive features and shorter DSS
- P = 0.001
Original publication
Tumor Grade and Molecular Characteristics Associated with Survival in Sporadic Medullary Thyroid Carcinoma. Thyroid. Published 4 December 2023. doi:10.
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