Comprehensive Long-Read Sequencing Analysis Discloses the Transcriptome Features of Papillary Thyroid Microcarcinoma
Authors' conclusion
Our data provided the global transcriptome landscape of PTMC and also revealed the novel isoforms that associated with PTMC aggressiveness.
Study context
- Population
- Papillary thyroid microcarcinoma (PTMC) samples
- Participants
- 64 PTMC samples
- Comparison
- pN1b vs pN0 PTMC subtypes
- Outcome
- PTMC transcriptome landscape
Methodological detailsfull-length (long-read) transcriptome sequencing
- Full-length (long-read) transcriptome sequencing
Main finding
As reported in the abstract
Skipping exons share of alternative splicing events
more than 27.82%
Discovered transcripts that were novel isoforms of annotated genes
At least 42.56%
Open reading frame (ORFs) in novel transcripts
39 193
ORFs in known transcripts
18 596
Further findings
| Outcome | pN0 | pN1b |
|---|---|---|
| Differentially expressed genes | 1033 | 1204 |
Differentially expressed genes
- Novel isoforms of FRMD3, NOD1 and SHROOM4 associated with pN1b subtype
Original publication
Comprehensive Long-Read Sequencing Analysis Discloses the Transcriptome Features of Papillary Thyroid Microcarcinoma. J Clin Endocrinol Metab. Published 1 December 2023. doi:10.
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