A Comparison of the Predictive Value of International Medullary Thyroid Carcinoma Grading System (IMTCGS) With That of Other Risk Factors in a Chinese Medullary Thyroid Carcinoma Cohort
Authors' conclusion
In this Chinese MTC cohort, IMTCGS was a powerful predictor of disease-specific death, while postoperative calcitonin was a powerful predictor of structural recurrence.
Study context
- Population
- Medullary thyroid carcinoma (MTC) patients undergoing initial surgery, January 2004–June 2023, Chinese cohort
- Participants
- 137 patients
- Exposure
- IMTCGS high vs low grade and other risk factors for progression-free survival (PFS) and disease-specific survival (DSS)
- Outcome
- PFS and DSS; predictive value of IMTCGS vs other risk factors
Methodological detailsHistologic features reviewed by two pathologists
- Histologic features reviewed by two pathologists
Main finding
As reported in the abstract
- IMTCGS, TNM stage, postoperative calcitonin, postoperative CEA and vascular invasion associated with PFS (Kaplan-Meier)
- all p < 0.05
- Postoperative calcitonin: only independent predictor of PFS (multivariate), HR
- 1.002, p = 0.002
- AUC for structural recurrence, postoperative calcitonin vs IMTCGS (Delong's test)
- 0.90 vs. 0.64, p = 0.002
- IMTCGS, TNM stage and vascular invasion associated with DSS (Kaplan-Meier)
- p < 0.05
- IMTCGS: only independent predictor of DSS (multivariate), HR
- 11.23, p = 0.05
- AUC of IMTCGS for disease-specific death
- 0.81 (p = 0.01)
Observational data: associations, not effects.
Further findings
Events
- Local recurrence
- 14/134 (10.45%)
- Distant metastasis
- 3/134 (2.24%)
- Disease-specific death
- 6/137 (4.38%)
Original publication
A Comparison of the Predictive Value of International Medullary Thyroid Carcinoma Grading System (IMTCGS) With That of Other Risk Factors in a Chinese Medullary Thyroid Carcinoma Cohort. Clin Endocrinol (Oxf). Published 3 January 2025. doi:10.
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