Association Between Serum Thyrotropin and Cancer Recurrence in Differentiated Thyroid Cancer: A Population-Based Retrospective Cohort Study
Authors' conclusion
There was no difference in clinically significant recurrence in those with low-risk DTC maintained with a TSH of 0.5-2 mIU/L compared with 2-4 mIU/L.
Study context
- Population
- Patients with differentiated thyroid cancer (DTC) post-thyroidectomy, Ontario, Canada, 2007–2018; 78% female, median age 50 years
- Participants
- 26,336 patients
- Exposure
- High-normal TSH vs low-normal TSH exposure
- Outcome
- Cancer recurrence after thyroidectomy, by exposure to high normal TSH (2-4 mIU/L) vs low normal TSH (0.5-2 mIU/L)
Methodological detailslinked administrative health care databases, time-updated exposure
- Linked administrative health care databases
- Time-updated exposure
Main finding
As reported in the abstract
DTC recurrence per additional 3 months of exposure
Each group vs TSH 0.5 to ≤2 mIU/LAdjusted cause-specific hazard ratio (CI)
TSH >2 to ≤4 mIU/Lsimilar recurrence rate
0.99(0.97–1.02)
TSH >4 mIU/L
1.07(1.04–1.09)
Observational data: associations, not effects.
Further findings
Sensitivity analysis stratified by initial treatment
- Results were similar across baseline treatment groups
Original publication
Association Between Serum Thyrotropin and Cancer Recurrence in Differentiated Thyroid Cancer: A Population-Based Retrospective Cohort Study. Thyroid. Published 26 December 2024. doi:10.
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