Trends in the Incidence, Organization of Care, and Surgical Treatment of Medullary Thyroid Cancer: A Population-Based Study
Authors' conclusion
This study shows a stable incidence and improved survival of MTC in the Dutch population over the last three decades.
Study context
- Population
- All patients with a histological medullary thyroid cancer (MTC) diagnosis between 1989 and 2018 in the Netherlands
- Participants
- 795 patients
- Exposure
- Period A vs period B vs period C
- Outcome
- Population-adjusted incidence of MTC
- Follow-up
- 30 years
Methodological detailsNetherlands Cancer Registry linked to Dutch Pathology register (PALGA), 30-year period comparison
- Netherlands Cancer Registry linked to Dutch Pathology register (PALGA)
- 30-year period comparison
Main finding
As reported in the abstract
Incidence remained stable, diagnoses per 100,000 people per year (p = 0.247)
0.17 ± 0.04
Observational data: associations, not effects.
Further findings
Treatment in an academic hospital
CND — Period C vs Period A · more frequent in period C
P = 0.009
Overall survival — Period C vs Period A · improved
P = 0.022
Years
| Outcome | Period A | Period B | Period C | P value |
|---|---|---|---|---|
| Age at diagnosisPeriod C vs Period A · increased over time | 42 (IQR 25–61) | — not stated in the abstract | 52 (IQR 42–63) | P < 0.001 |
| CNDPeriod C vs Period B · more frequent in period C | P = 0.027 | |||
| Overall survivalPeriod C vs Period B · improved | P = 0.007 |
— not stated in the abstract
- Treatment in an academic hospital: both p < 0.001
Patient characteristics
- Female
- 54%
- Treated in an academic hospital
- 63%
- Median age, years (IQR 34-61)
- 48
Lymph node (LN) dissection at primary treatment
- LN dissection performed
- 582 (73%)
- Of these, central neck dissection (CND)
- 88%
- Of these, unilateral neck dissection
- 36%
- Of these, bilateral neck dissection
- 20%
Locoregional recurrence
- Locoregional recurrence rates remained stable
Original publication
Trends in the Incidence, Organization of Care, and Surgical Treatment of Medullary Thyroid Cancer: A Population-Based Study. Thyroid. Published 20 December 2024. doi:10.
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