Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year–A cross-sectional and prospective analysis
Authors' conclusion
Incretins, glucagon and glicentin profiles in prediabetic state cannot predict future glycemic traits, but prediabetes progressing to diabetes is accompanied by deterioration of postprandial increases of GLP-1 and glicentin.
Study context
- Population
- Subjects who all had prediabetes one year before; GLP-1, glucagon, GIP and glicentin measured during OGTT106 with 1-year-prior data
- Participants
- 125 subjects
- Exposure
- Prediabetes progressing to diabetes vs regressing to normal glucose tolerance (NGT)
- Diabetesn = 30
- Prediabetesn = 65
- NGTn = 30reference
- Outcome
- GI hormone levels during OGTT
Methodological details5-timepoint OGTT, one-year follow-up
- 5-timepoint OGTT
- One-year follow-up
Main finding
As reported in the abstract
- At baseline (all prediabetic), hormonal levels did not differ between groups
- One year later, progression to diabetes vs regression to NGT: lower postprandial increases of glicentin and GLP-1, lower postprandial decrease of glucagon, higher fasting GIP
Observational data: associations, not effects.
Further findings
Correlations of 1-year changes · one year
- Changes in glicentin and GLP-1 AUC correlated negatively with changes in glucose AUC of OGTT and with changes in β-cell function markers
Original publication
Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year–A cross-sectional and prospective analysis. Diabetes Res Clin Pract. Published 20 March 2023. doi:10.
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