Earlier Age at Type 2 Diabetes Diagnosis Is Associated With Increased Genetic Risk of Cardiovascular Disease
Authors' conclusion
Individuals with an earlier T2D diagnosis have a higher genetic risk of CAD, and this information could be used to tailor lifestyle interventions.
Study context
- Population
- Individuals with T2D in UK Biobank and the Seoul National University Hospital (SNUH) cohortUK Biobank 12,321 · Individuals with T2D in UK Biobank 12,321 · SNUH cohort 1,165
- Exposure
- Effect of coronary artery disease (CAD) polygenic risk score (PRS) on incident CAD by age at T2D diagnosis
- Outcome
- Incident CAD (effect size of CAD PRS) by age at T2D diagnosis
Methodological detailstwo cohorts (UK Biobank and SNUH), polygenic risk score
- Two cohorts (UK Biobank and SNUH)
- Polygenic risk score
Main finding
As reported in the abstract
Effect of CAD PRS on incident CAD by age at T2D diagnosis (UK Biobank)
Hazard ratio per CAD PRS (95% CI)P value
Age 30-39 years at T2D diagnosis
2.25(1.56–3.26)
Age 40-49 years at T2D diagnosis
1.51(1.30–1.75)
Age 50-59 years at T2D diagnosis
1.36(1.24–1.50)
Age 60-69 years at T2D diagnosis
1.30(1.14–1.48)
P = 0.0031for interactionObservational data: associations, not effects.
Further findings
Effect of CAD PRS by age at T2D diagnosis, SNUH cohort
- A similar trend was observed in the SNUH cohort
Healthy lifestyle
- Increased genetic risk with earlier T2D diagnosis largely mitigated by a healthy lifestyle
Original publication
Earlier Age at Type 2 Diabetes Diagnosis Is Associated With Increased Genetic Risk of Cardiovascular Disease. Diabetes Care. Published 20 March 2023. doi:10.
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