Genetic Susceptibility to Diabetes Subtypes and Risk of Developing Coronary Artery Disease
Main finding · Incident CAD by PRSMOD tertileResult — go to the resultFold higher risk 1.10Authors' conclusion
The current study showed that the genetic susceptibilities for all five diabetes subtypes were associated with incident diabetes. However, only the MOD subtype was associated with incident CAD. These findings underscore the significance of a high genetic risk for MOD as an early marker for CAD.
Study context
- Population
- General population, Malmö Diet and Cancer cohort; GWAS data of the MOD subtype and coronary artery disease (CAD)Malmö Diet and Cancer cohort · GWAS data of the MOD subtype 4,116 · CAD 296,525
- Participants
- 24,025 participants
- Exposure
- Third vs first tertile of PRS for MOD
- Outcome
- Incident diabetes and CAD predicted by polygenic risk scores (PRSs) for the five diabetes subtypes
Methodological detailspolygenic risk scores, population-based cohort
- Polygenic risk scores
- Population-based cohort
Main finding
Incident CAD by PRSMOD tertile
Fold higher risk
1.10
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incidence during follow-up
- Developed diabetes (median follow-up 24.0 years)
- 4,105 (17.1%)
- Developed CAD (median follow-up 24.6 years)
- 3,841 (16.0%)
Genetic correlation and Mendelian randomization, MOD and CAD
- Positive genetic correlation between MOD and CAD; MR suggested a causal effect of MOD on CAD
Original publication
Genetic Susceptibility to Diabetes Subtypes and Risk of Developing Coronary Artery Disease. Diabetes Care. Published 30 March 2026. doi:10.
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