Prognostic Value of Coronary CT Angiography Among Patients With and Without Diabetes: The Mass General Brigham CCTA registry
Authors' conclusion
Among patients undergoing CCTA, CAD was more frequent and severe in those with diabetes, and the risk of CVD or MI increased with CAD severity, approximately doubling in each category when diabetes was present.
Study context
- Population
- Patients undergoing CCTA at two medical centers, 2006–2024, without prior coronary artery disease (CAD), advanced kidney disease or malignancy; median age 56 (IQR 47–65); 45% women
- Participants
- 22,377 patients
- Exposure
- Patients with diabetes mellitus (DM) vs without DM
- DMn = 3,245
- Outcome
- Composite of:
- CV death
- Myocardial infarction (MI)
- Follow-up
- Median 6 years (IQR 3.9-9.5)
Methodological detailstwo medical centers, registry
- Two medical centers
- Registry
Main finding
As reported in the abstract
Composite of:
- CVD
- MI
- Primary outcome occurred more than twice as often with DM
- DM vs non-DM: P < 0.001
Observational data: associations, not effects.
Further findings
Obstructive CAD and primary outcome, adjusted
| HR (95% CI) | P value | ||
|---|---|---|---|
| Obstructive CAD (DM)DM · after adjustment | 2.9 (1.8–4.6) | P < 0.001 | |
| Obstructive CAD (non-DM)non-DM · after adjustment | 2.7 (2.1–3.4) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
CAD severity on CCTA
- Obstructive CAD more frequent with DM
- No CAD less common with DM
Primary outcome by CAD category
- Event rates increased with CAD severity and remained higher with DM across all categories
Original publication
Prognostic Value of Coronary CT Angiography Among Patients With and Without Diabetes: The Mass General Brigham CCTA registry. Cardiovasc Diabetol. Published 15 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →