Elevated Cardiovascular Risk and Mortality in Type 2 Diabetes Mellitus Patients With Cannabis, Opioid, and Cocaine Use Disorders
Authors' conclusion
Co-occurring SUDs are strongly associated with increased risk of cardiovascular morbidity and all-cause mortality in T2DM patients. However, these associations should be interpreted cautiously due to potential residual confounding despite propensity score matching.
Study context
- Population
- Adults aged ≥18 years diagnosed with T2D between January 2016 and December 2022, TriNetX Research Networkafter propensity score matching (PSM)
- Participants
- 69,419 vs 69,419
- Exposure
- SUD vs no SUD
- SUDn = 69,419
- Non-SUDn = 69,419reference
- Outcome
- Cardiovascular disease (CVD) and all-cause mortality
- Follow-up
- 3-year follow-up
Methodological detailspropensity-score matched, TriNetX Research Network
- Propensity-score matched
- TriNetX Research Network
Main finding
As reported in the abstract
SUD vs Non-SUDHazard ratio (95% CI)P value
Acute MI
1.994(1.766–2.253)
P < 0.001AF
1.455(1.300–1.630)
P < 0.001HF
1.837(1.693–1.994)
P < 0.001Stroke
1.524(1.354–1.715)
P < 0.001All-cause mortality
1.420(1.359–1.483)
P < 0.001Observational data: associations, not effects.
Further findings
Subgroups by substance type
- Consistent risk elevations across all substance types; highest relative mortality risk with opioid-related disorders
Original publication
Elevated Cardiovascular Risk and Mortality in Type 2 Diabetes Mellitus Patients With Cannabis, Opioid, and Cocaine Use Disorders. Diabetes Obes Metab. Published 15 June 2026. doi:10.
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