Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study
Authors' conclusion
Poor reproducibility and lack of classification concordance highlight the limitations of one-time testing, with important implications for assessing eligibility in clinical trials. Consideration should be given to using more than a single parameter for screening and diagnosis, especially when classification category is important.
Study context
- Population
- Dysglycemic youth and adults in the Restoring Insulin Secretion Study
- Participants
- 66 vs 354
- Comparison
- Youth vs adults
- Youthn = 66
- Adultsn = 354reference
- Primary endpoint
- Variability (change, CV) and classification concordance for HbA1c, fasting and 2-hour OGTT glucose between 2 visits
- Follow-up
- ∼6 weeks apart
Methodological detailsreproducibility study, repeated samples ∼6 weeks apart
- Reproducibility study
- Repeated samples ∼6 weeks apart
Primary result
As reported in the abstract
∼6 weeks
- Coefficient of variation (CV) smallest for hemoglobin A1C (HbA1c) vs fasting and 2-hour glucose
- Youth vs Adults: P < 0.001
- Youth vs Adults: P = 0.051
- Youth vs Adults: P < 0.001
- Youth vs Adults: P = 0.041
- Youth vs Adults: P = 0.004
Further findings
Discordant classification using OGTT or HbA1c
| Outcome | Youth | Adults |
|---|---|---|
| Discordant classification using both fasting glucose and HbA1c | — not stated in the abstract | 16% |
— not stated in the abstract
Discordant classification using both fasting glucose and HbA1c
- No improvement in classification in youth
Original publication
Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study. J Clin Endocrinol Metab. Published 20 March 2023. doi:10.
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