Associations of combined polygenic risk score and glycemic status with atrial fibrillation, coronary artery disease and ischemic stroke
Authors' conclusion
Our results suggest that the nature of the dose-dependent relationship between HbA1c levels and cardiovascular disease in individuals with different PRS is outcome-specific. This adds to the evidence that PRS may play a role together with glycemic status in the development of cardiovascular disease.
Study context
- Population
- Unrelated UK Biobank participants aged 40–70 years with available polygenic risk score (PRS); 52.9% female, mean age 56.6 years
- Participants
- 305,605 participants
- Exposure
- Hemoglobin A1c (HbA1c) categories within PRS tertiles vs HbA1c < 5.7% and low PRS
- Outcome
- New-onset AF, coronary artery disease and ischemic stroke
- Follow-up
- Median 11.9 (IQR 11.1-12.6) years
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
AF, CAD, ischemic stroke
Each group vs HbA1c < 5.7% and low PRSEstimate (95% CI)
HbA1c ≥ 6.5% and high PRS
HR (AF) 2.67(2.43–2.94)
HbA1c ≥ 6.5% and high PRS
HR (CAD) 5.71(5.14–6.33)
HbA1c ≥ 6.5% and high PRS
HR (ischemic stroke) 2.94(2.47–3.50)
Per 100 person-years
- Incidence of atrial fibrillation (AF)
- 4.6
- Incidence of coronary artery disease (CAD)
- 2.9
- Incidence of ischemic stroke
- 1.1
Observational data: associations, not effects.
Further findings
Restricted cubic spline: HbA1c vs risk
- U-shaped trend between HbA1c and AF risk; dose-dependent increases for CAD and ischemic stroke regardless of PRS tertile
Original publication
Associations of combined polygenic risk score and glycemic status with atrial fibrillation, coronary artery disease and ischemic stroke. Cardiovasc Diabetol. Published 3 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →