Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries
Authors' conclusion
Genetic effects need to be considered to personalize HbA1c targets and improve outcomes of people with diabetes from diverse ancestries.
Study context
- Population
- T2D cases of genetically inferred African American/African British and European ancestriesT2D cases
- Participants
- 29,828 cases
- Comparison
- Bottom quintile vs above bottom quintile of nonglycemic hemoglobin A1c (HbA1c) polygenic score (ngA1cPS)
- Outcome
- Retinopathy, adjusted for measured HbA1c and retinopathy risk factors
Methodological detailsmeta-analysis, ancestry-specific polygenic scores
- Meta-analysis
- Ancestry-specific polygenic scores
Pooled result
As reported in the abstract
Retinopathy
Each group vs above bottom quintileEstimate (95% CI)P value
Bottom quintile
adjusted meta-analytic OR (African ancestry) 1.31(1.0–1.73)
P = 0.05Bottom quintile
adjusted meta-analytic OR (European ancestry) 1.31(1.15–1.50)
P = 6.5 × 10-5- Retinopathy prevalence higher in bottom quintile vs above, despite similar measured HbA1c
- between 20% and 50% higher
Further pooled results
Retinopathy prevalence, African ancestry with HbA1c below 7%
- Higher below vs above the 50th percentile of the ngA1cPS regardless of sex or G6PD carrier status
Original publication
Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries. Diabetes Care. Published 23 July 2024. doi:10.
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