Association Between Plasma LRG1 and Lower Cognitive Function in Asians With Type 2 Diabetes Mellitus
Authors' conclusion
Baseline plasma LRG1 was associated with lower cognitive function at follow-up in patients with T2DM, mediated by PWV. MR analysis provided evidence of an association between genetically influenced plasma LRG1 and lower cognitive function at follow-up.
Study context
- Population
- Asian patients with T2D; age 64.1 ± 6.4 years; follow-up 5.3 ± 1.2 years
- Participants
- 1,039 patients
- Exposure
- Higher vs lower baseline plasma LRG1
- Outcome
- Longitudinal association between plasma LRG1 and cognitive function (RBANS total score)
- Follow-up
- 5.3 ± 1.2 years
Methodological detailslongitudinal, one-sample Mendelian randomization, mediation analysis
- Longitudinal
- One-sample Mendelian randomization
- Mediation analysis
Main finding
As reported in the abstract
Baseline Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total score: adjusted coefficient
−1.38
95% CI −2.55 to −.21P = .021
Follow-up RBANS total score: adjusted coefficient
−1.38
95% CI −2.70 to −.07P = .039
Observational data: associations, not effects.
Further findings
Mendelian randomization (MR): genetically predicted plasma LRG1 (rs4806985) and follow-up RBANS total score, per unit increase in LnLRG1
- Coefficient
- −7.44 (95% CI −14.14 to −.74; P = .030)
Mediation by pulse wave velocity (PWV) of LnLRG1–follow-up RBANS total score association
- Proportion accounted for by higher PWV
- 27.7%
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →