Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year
Authors' conclusion
We identify new candidates associated with the progression of prediabetes to diabetes or its remission to normoglycemia. Pathways regulating the immune response are related to prediabetes trajectories.
Study context
- Population
- Individuals with new-onset diabetes, prediabetes or normal glucose tolerance, all with prediabetes 1 year before108 with 1-year-prior samples
- Participants
- 134 individuals
- Comparison
- Prediabetes progressing to diabetes vs reversing to normoglycemia within 1 year
- Outcome
- Proteomic and metabolomic differences
- Follow-up
- 1 year
Methodological detailsproteomic and metabolomic profiling, longitudinal (1 year), Fasting plasma 1,389 proteins; fasting, 30-min and 120-min post-OGTT plasma 152 metabolites
- Proteomic and metabolomic profiling
- Longitudinal (1 year)
- Fasting plasma 1,389 proteins; fasting, 30-min and 120-min post-OGTT plasma 152 metabolites
Main finding
As reported in the abstract
1 year
- Proteins higher in diabetes vs normoglycemia (prediabetes 1 year before), correlated with insulin sensitivity indices
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Original publication
Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year. Diabetes Care. Published 2 January 2025. doi:10.
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