Childhood Obesity and Age‐Related Diseases: A Systematic Review and Meta‐Analysis of Mendelian Randomization Evidence
Authors' conclusion
The findings from this meta-analysis underscore associations between childhood adiposity and multisystem age-related pathologies, underscoring the imperative for early obesity prevention.
Study context
- Population
- MR studies of paediatric adiposity and major age-related diseases; six databases screened45 MR articles
- Comparison
- Genetically determined childhood obesity and risk of age-related diseases
- Outcome
- Associations of genetically determined childhood obesity with age-related diseases
Methodological detailsde novo MR analyses using UK Biobank, FinnGen and other large consortiums
- De novo MR analyses using UK Biobank, FinnGen and other large consortiums
Pooled result
As reported in the abstract
Age-related diseases (44 diseases across 9 systems)
Suggestive associations of genetically determined childhood obesity with increased risk of age-related diseases
16
Marginal associations (p = 0.03-0.05)
3
Original publication
Childhood Obesity and Age‐Related Diseases: A Systematic Review and Meta‐Analysis of Mendelian Randomization Evidence. Pediatr Obes. Published 14 November 2025. doi:10.
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