Characterizing trajectories of diabetes-related health parameters before diabetes diagnosis in diabetes subtypes: analysis of a 20-year long prospective cohort study in Sweden
Authors' conclusion
In a Swedish population, trajectories of diabetes-related health parameters differed up to 20 years before diagnosis between the T2D-related subtypes and controls. This might support early prediction of subtype-specific risks for long-term complications, allowing early initiation of personalized treatment strategies.
Study context
- Population
- Participants of the Stockholm Diabetes Prevention Programme cohort (SDPP), Sweden, with recent onset T2D, and diabetes-free controls215 T2D, 2531 controls
- Exposure
- Trajectories of diabetes-related health parameters across T2D subtypes (severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), MOD, mild age-related diabetes (MARD)) vs controls
- Controlsn = 2,531reference
- Outcome
- Trajectories of FPG, insulin, BMI, HOMA2-B, HOMA2-IR, WHR, DBP and SBP
- Follow-up
- Up to 20 years before and 10 years after T2D diagnosis
Methodological details20-year, multilevel longitudinal mixed-effects models
- 20-year
- Multilevel longitudinal mixed-effects models
Main finding
As reported in the abstract
Trajectories of diabetes-related health parameters · up to 20 years before diagnosis
- SIDD consistently had the highest fasting plasma glucose (FPG) concentrations
- P < 0.001
- Body mass index (BMI) higher in MOD and SIRD than in SIDD and MARD throughout the study period
- P < 0.01
- SIRD had the highest fasting insulin and higher HOMA2-IR than MOD and MARD
- P < 0.001
- SIDD had higher systolic blood pressure (SBP) than MOD
- P = 0.03
Observational data: associations, not effects.
Original publication
Characterizing trajectories of diabetes-related health parameters before diabetes diagnosis in diabetes subtypes: analysis of a 20-year long prospective cohort study in Sweden. Cardiovasc Diabetol. Published 9 June 2025. doi:10.
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