Identification of pre-diabetes subphenotypes for type 2 diabetes, related vascular complications and mortality
Authors' conclusion
Our pre-diabetes phenotyping approach effectively provides valuable insights into the risk of type 2 diabetes, vascular complications and mortality in individuals with pre-diabetes. Those with high-risk phenotypes should be prioritized for type 2 diabetes and cardiovascular interventions to mitigate risks.
Study context
- Population
- Adults without T2D with baseline HbA1c and fasting plasma glucose (FPG), Siriraj Hospital, Bangkok, Thailand; mean age 60.1±10.1 years, 54.6% female; clustered on age, BMI, FPG, HbA1c, HDL-C and alanine aminotransferase
- Participants
- 4,915 adults
- Exposure
- Six pre-diabetes subphenotype clusters
- Cluster 1n = 650reference
- Cluster 2n = 791
- Cluster 3n = 1,127
- Cluster 4n = 963
- Cluster 5n = 337
- Cluster 6n = 1,042
- Outcome
- Incidence of T2D, long-term vascular complications and mortality across subphenotypes
- Follow-up
- Median 8.8 years
Methodological detailsk-means clustering, single-centre
- K-means clustering
- Single-centre
Main finding
As reported in the abstract
Incidence of T2D, vascular complications and mortality by pre-diabetes cluster
- Diabetes risk subgroups: low risk (clusters 1 and 4) and high risk (clusters 3 and 5)
- Cox regression adjusted for sex, statin use and hypertension status
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Identification of pre-diabetes subphenotypes for type 2 diabetes, related vascular complications and mortality. BMJ Open Diabetes Res Care. Published 9 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →