Circulating small non‐coding RNAs are associated with the insulin‐resistant and obesity‐related type 2 diabetes clusters
Authors' conclusion
Our research showed differential sncRNA levels among type 2 diabetes clusters. This may reflect and could deepen our understanding of molecular mechanisms, in development, progression, and risk factors for each cluster.
Study context
- Population
- Individuals with T2D in the Hoorn Diabetes Care System (DCS) cohort, clustered by age, body mass index (BMI), HbA1c, C-peptide and HDL-Cvalidation n = 138
- Participants
- 412 individuals
- Exposure
- Circulating small non-coding RNAs (sncRNAs) across five T2D clusters
- Outcome
- Differentially expressed sncRNAs by cluster
Methodological detailsplasma sncRNA-sequencing, validation dataset
- Plasma sncRNA-sequencing
- Validation dataset
Main finding
As reported in the abstract
- Insulin-resistant cluster: sncRNAs with aberrant expression
- 10
- High BMI cluster: differentially expressed sncRNAs
- eight
Observational data: associations, not effects.
Original publication
Circulating small non‐coding RNAs are associated with the insulin‐resistant and obesity‐related type 2 diabetes clusters. Diabetes Obes Metab. Published 10 July 2024. doi:10.
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