Depression symptoms, wellbeing, health-related quality of life, and diabetes-related distress in novel subtypes of recent-onset diabetes in Germany: a 5-year observational follow-up study
Authors' conclusion
Diabetes subtypes already differ in PROs at diabetes diagnosis. Our analyses had limited predictive power during follow-up. However, our findings suggest that clustering could predict future changes in depression symptoms.
Study context
- Population
- German Diabetes Study (GDS) participants with recent-onset diabetes (<12 months after diagnosis)
- Participants
- 1,391 baseline cluster analyses
- Exposure
- Novel diabetes subtypes and patient-reported outcomes (PROs)
- Severe autoimmune diabetes (SAID)n = 417
- Severe insulin-deficient diabetes (SIDD)n = 33
- Severe insulin-resistant diabetes (SIRD)n = 150
- MODn = 354
- Mild age-related diabetes (MARD)n = 437reference
- Outcome
- PROs: depression symptoms (CES-D), wellbeing (WHO-5), HRQOL (SF-36), diabetes-related distress (PAID)
- Follow-up
- baseline and 5-year follow-up
Methodological details5-year observational follow-up, cluster analysis
- 5-year observational follow-up
- Cluster analysis
Main finding
As reported in the abstract
PROs at baseline by subtype
- SIRD had higher depression symptoms than MARD and lower physical HRQOL than all other subtypes
- SAID had higher depression symptoms and lower mental HRQOL than MARD, higher physical HRQOL than MARD and MOD, and higher diabetes-related distress than most other subtypes
- Multiple regression analyses
Observational data: associations, not effects.
Further findings
Clinically relevant depression symptoms (descriptive) · 5-year follow-up · descriptive analyses
Low wellbeing (descriptive) · 5-year follow-up · descriptive analyses
Prediction of PRO changes by clustering · 5-year follow-up
- Clustering predicted no statistically significant changes in PROs after adjustment for multiple testing
Original publication
Depression symptoms, wellbeing, health-related quality of life, and diabetes-related distress in novel subtypes of recent-onset diabetes in Germany: a 5-year observational follow-up study. Lancet Diabetes Endocrinol. Published 24 October 2024. doi:10.
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