Cardiovascular risk in patients with acromegaly vs. non-functioning pituitary adenoma following pituitary surgery: an active-comparator cohort study
Main finding · Composite cardiovascular events and all-cause mortalityResult — go to the resultHazard ratio 0.64 95% CI 0.31–1.32Authors' conclusion
This cohort study did not find an increased risk of cardiovascular outcomes and mortality in patients with acromegaly undergoing pituitary surgery compared to surgically treated NFPA patients. These findings suggest that there is no legacy effect regarding higher cardio-metabolic risk in individuals with acromegaly once they receive surgical treatment.
Study context
- Population
- Hospitalized patients with acromegaly or non-functioning pituitary adenoma (NFPA) undergoing pituitary surgery in Switzerland, January 2012–December 2021propensity score-matched
- Participants
- 231 vs 491
- Exposure
- Acromegaly vs NFPA following pituitary surgery
- Acromegalyn = 231
- NFPAn = 491reference
- Outcome
- Composite of:
- Cardiovascular events (MI, cardiac arrest, ischemic stroke, hospitalization for HF, unstable angina pectoris, cardiac arrhythmias, intracranial hemorrhage, hospitalization for hypertensive crisis)
- All-cause mortality
Methodological detailsactive-comparator, 1:3 propensity score matching
- Active-comparator
- 1:3 propensity score matching
Main finding
As reported in the abstract
Composite:
- Cardiovascular events
- All-cause mortality
Hazard ratio
0.64
95% CI 0.31–1.32
By group
Acromegaly
8.18 per 1,000 person-years
NFPA
12.73 per 1,000 person-years
Acromegalyvs NFPA
HR 0.64 (95% CI 0.31–1.32)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Acromegaly | NFPA | HR (95% CI) | |
|---|---|---|---|---|
| MortalityNumerically lower with acromegaly | 2.43 deaths per 1,000 person-years | 7.05 deaths per 1,000 person-years | 0.34 (0.10–1.17) | |
| 0.10.31310Hazard ratio (log scale) |
Individual components of the primary outcome and in-hospital outcomes
- No significant differences between the groups
Original publication
Cardiovascular risk in patients with acromegaly vs. non-functioning pituitary adenoma following pituitary surgery: an active-comparator cohort study. Pituitary. Published 31 May 2024. doi:10.
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