Long-term outcomes in patients with Cushing's disease vs nonfunctioning pituitary adenoma after pituitary surgery: an active-comparator cohort study
Main finding · Primary composite endpointResult — go to the resultHazard ratio 2.75 95% CI 1.54–4.90Authors' conclusion
Even after pituitary surgery, CD patients faced a higher hazard of complications, especially psychiatric hospitalizations and sepsis.
Study context
- Population
- Hospitalized patients undergoing pituitary surgery for Cushing's disease (CD) or nonfunctioning pituitary adenoma (NFPA), Swiss Federal Statistical Office data, January 2012–December 2021propensity score matched
- Participants
- 116 vs 396
- Exposure
- CD vs NFPA after pituitary surgery
- CDn = 116
- NFPAn = 396reference
- Outcome
- Composite of:
- All-cause mortality
- MACE (MI, unstable angina, HF, cardiac arrest, ischemic stroke)
- Hospitalization for psychiatric disorders
- Sepsis
- Severe thromboembolic events
- Fractures needing hospitalization
- Follow-up
- Median 50.0 months (IQR 23.5, 82.0)
Methodological details1:5 propensity score matching, active-comparator
- 1:5 propensity score matching
- Active-comparator
Main finding
Primary composite endpoint
Hazard ratio
2.75
95% CI 1.54–4.90
By group
CD
40.6 events per 1000 person-years
NFPA
15.7 events per 1000 person-years
CDvs NFPA
HR 2.75 (95% CI 1.54–4.90)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Hospitalization for psychiatric disorders | 3.27 (1.59–6.71) | |
| SepsisTrend | 3.15 (.95-10.40) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Long-term outcomes in patients with Cushing's disease vs nonfunctioning pituitary adenoma after pituitary surgery: an active-comparator cohort study. Eur J Endocrinol. Published 1 July 2024. doi:10.
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