Automated Insulin Delivery Reduces the Risk of Diabetic Retinopathy in Adults with Type 1 Diabetes: A Prospective Cohort Study
Main finding · Incident DRResult — go to the resultHazard ratio 0.33 95% CI 0.13–0.73Authors' conclusion
AID systems were associated with improved glycemic control and reduced incidence and progression of DR in adults with T1D.
Study context
- Population
- Adults with T1D; Diabetic retinopathy (DR) assessed via standardized retinal imaging; mean follow-up 4.9 ± 1.4 years
- Participants
- 379 adults
- Exposure
- Automated insulin delivery (AID) vs multiple daily injections (MDI)
- MDIn = 264reference
- Outcome
- Incident DR
- Follow-up
- Mean 4.9 ± 1.4 years
Methodological detailsmultivariate Poisson and Cox regression adjusted for age, diabetes duration, pre-baseline HbA1c, propensity score-matched and HbA1c trajectory sensitivity analyses
- Multivariate Poisson and Cox regression adjusted for age, diabetes duration, pre-baseline HbA1c
- Propensity score-matched and HbA1c trajectory sensitivity analyses
Main finding
As reported in the abstract
Hazard ratio
0.33
95% CI 0.13–0.73
P = 0.01
By group
AIDvs MDI
HR 0.33 (95% CI 0.13–0.73); P = 0.01
Observational data: associations, not effects.
Further findings
DR progression and all vision-threatening events · occurred only in the MDI group
P < 0.001
%
| Outcome | AID | MDI | P value |
|---|---|---|---|
| Change in HbA1c | −0.32 | −0.06 | P = 0.01 |
DR prevalence at baseline
- DR prevalence at baseline, no group differences
- 13.9%
Original publication
Automated Insulin Delivery Reduces the Risk of Diabetic Retinopathy in Adults with Type 1 Diabetes: A Prospective Cohort Study. Diabetes Technol Ther. Published 5 February 2026. doi:10.
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