A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery
Primary result · Area under the curve for glucose >180 mg/dLResult — go to the resultAdjusted difference −12 mg/dL 95% CI −22 to −2Authors' conclusion
Postmeal glucose excursion was smaller with TI than with RAA insulin in a cohort that included both AID and MDI users.
Study context
- Population
- Adults with T1D using multiple daily injections (MDI), a nonautomated pump or automated insulin delivery (AID), undergoing a meal challenge
- Participants
- 122 adults
- Comparison
- Inhaled technosphere insulin (TI) vs subcutaneous rapid-acting analog (RAA) insulin bolus
- TIn = 61
- RAAn = 61reference
- Primary endpoint
- Treatment group difference in area under the curve for glucose >180 mg/dL
- Follow-up
- Over 2 h
Primary result
Area under the curve for glucose >180 mg/dL · 2 h
Adjusted difference
−12 mg/dL
95% CI −22 to −2
P = 0.02
TIvs RAA
adjusted difference −12 mg/dL (95% CI −22 to −2); P = 0.02
As reported in the abstract
Further findings
- Glucose excursion smaller with TI
- P = 0.01
- Peak glucose lower with TI
- P = 0.01
- Time to peak glucose shorter with TI
- P = 0.006
Safety
Events
| Outcome | TI | RAA |
|---|---|---|
| Blood glucose <70 mg/dL | 1 | 1 |
Original publication
A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery. Diabetes Care. Published 23 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →