MiniMed TM 780G Hybrid Closed-Loop Systems Improves Markers of Vascular and Endothelial Function in Patients with Type 1 Diabetes: Association with Continuous Glucose Monitoring Metrics
Authors' conclusion
MiniMedTM 780G HCLS demonstrated superiority over MDI or SGLT-2i in terms of glycemic control and cardiovascular function in T1D.
Study context
- Population
- Patients with poorly controlled T1D under MDI treatment
- Participants
- 90 consecutive patients
- Exposure
- HCL vs SGLT2i added to MDI vs intensified MDI
- Outcome
- Vascular function (PWV, cSBP, central diastolic blood pressure (cDBP)) and endothelial glycocalyx integrity (PBR of sublingual arterial microvessels)
- Follow-up
- 6 and 12 months
Methodological detailsconsecutive patients, three treatment groups
- Consecutive patients
- Three treatment groups
Main finding
As reported in the abstract
Change in PWV, cSBP and PBR · 12 months
| Group | Pulse wave velocity (PWV) change | Central systolic blood pressure (cSBP) change | Perfused boundary region (PBR) change |
|---|---|---|---|
| HCLS | −15.71% | −8.15% | −6.98% |
| SGLT-2i | −10.14% | −6.88% | −8.98% |
| MDI | +5.67% | +1.49% | +1.99% |
Pulse wave velocity (PWV) change
HCLS−15.71%
SGLT-2i−10.14%
MDI+5.67%
Central systolic blood pressure (cSBP) change
HCLS−8.15%
SGLT-2i−6.88%
MDI+1.49%
Perfused boundary region (PBR) change
HCLS−6.98%
SGLT-2i−8.98%
MDI+1.99%
- HCLS and SGLT-2i vs MDI: P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | HCLS | SGLT-2i | MDI | P value |
|---|---|---|---|---|
| Change in TIR · 6 monthsHCLS vs SGLT-2i | +28.61 | +10.91 | +2.11 | P = 0.026 |
| Change in TIR · 6 monthsHCLS and SGLT-2i vs MDI | P < 0.001 for all comparisons |
- Change in time in range (TIR) · 12 months · HCLS vs SGLT-2i · 2-fold higher increase
- P = 0.026
- Change in TIR · 12 months · HCLS vs MDI · 4-fold higher increase
- P < 0.001
Association of change in PWV, PBR and cSBP with change in TIR
- Absolute change of PWV, PBR and cSBP associated with absolute change of TIR
- P < 0.05
Original publication
MiniMed TM 780G Hybrid Closed-Loop Systems Improves Markers of Vascular and Endothelial Function in Patients with Type 1 Diabetes: Association with Continuous Glucose Monitoring Metrics. Diabetes Technol Ther. Published 5 February 2026. doi:10.
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