Should people with type 2 diabetes treated by multiple daily insulin injections with home health care support be switched to hybrid closed‐loop? The CLOSE AP + randomized controlled trial
Primary result · TIR 70-180 mg/dlResult — go to the resultIncrease in TIR 27.4 % 95% CI 15.0–39.8Authors' conclusion
AID combined with tailored HHC services significantly improved glycaemic control with no safety issues in people with type 2 diabetes previously under an MDI regimen with HHC. AID should be considered a safe option in these people when lacking acceptable glucose control.
Study context
- Population
- Adults with T2D using MDI, unable to manage MDI at home on their own and requiring nursing support
- Participants
- 30 adults
- Comparison
- Automated insulin delivery (AID) assisted by home health care (HHC) vs continued MDI with HHC
- Primary endpoint
- Percentage TIR 70-180 mg/dl
- Follow-up
- 12-week period
Methodological detailsopen label, multicentre, parallel group, Both treatments managed with support of HHC services
- Open label
- Multicentre
- Parallel group
- Both treatments managed with support of HHC services
Primary result
TIR 70-180 mg/dl · 12 weeks
Increase in TIR
27.4 %
95% CI 15.0–39.8
P < 0.001
AIDvs MDI
increase in TIR 27.4 % (95% CI 15.0–39.8); P < 0.001
As reported in the abstract
Secondary outcomes
| Outcome | Estimate |
|---|---|
| Time above rangeLower with AID | decrease 27.7 % |
| HbA1cFavouring AID | between-group difference 1.3 % |
Time below range
- Unchanged time below range
- <1%
Satisfaction
- Patient and caregiver satisfaction with AID was high
Safety
- Neither severe hypoglycaemia nor ketoacidosis occurred in either group
- 0
Original publication
Should people with type 2 diabetes treated by multiple daily insulin injections with home health care support be switched to hybrid closed‐loop? The CLOSE AP + randomized controlled trial. Diabetes Obes Metab. Published 3 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →