Lipids & metabolic liver disease
Atherogenic lipid parameters in people with normal glucose tolerance: implications from elevated 1-hour post-load plasma glucose
Authors' conclusion
NGT-1hPG-high exhibited a similar atherogenic lipid profile to that observed in PDM. 1-h PG could serve as a potential indicator for the early identification of at-risk individuals who may otherwise go undetected among NGT population.
Study context
- Population
- Individuals aged 25–55 years at high risk of diabetes, Daqing Diabetes Prevention Study II (Daqing DPS-II)
- Participants
- 2,469 individuals
- Exposure
- Glycemic status stratified by 1-h PG
- Outcome
- Distribution of glycemic status
Main finding
As reported in the abstract
Odds ratio
1.13
95% CI 0.88–1.44
P > 0.05
By group
Observational data: associations, not effects.
Further findings
Lipid profile by 1-h PG level
- Higher 1-h PG associated with increased TC, TG, LDL-C, ApoB, sdLDL-C, non-HDL-C, remnant cholesterol (RC) and ApoB/ApoA-1, and decreased ApoA-1, HDL-C and LDL-C/ApoB
- all P < 0.05
Spearman correlation of lipid parameters with 10-year cardiovascular disease (CVD) risk (China-PAR)
- TG
- 0.41
- sdLDL-C
- 0.38
- RC
- 0.35
- ApoB/ApoA-1
- 0.31
- LDL-C/ApoB
- - 0.37
- HDL-C
- - 0.36
Lipids, NGT-1hPG-high vs NGT-1hPG-normal
- TG, sdLDL-C and ApoB/ApoA-1 significantly higher; HDL-C and LDL-C/ApoB significantly lower with NGT-1hPG-high
- all P < 0.05
Lipids, NGT-1hPG-high vs PDM
- TG and RC differed
- both P < 0.01
- Most other lipid parameters did not significantly differ
- all P > 0.05
Original publication
Atherogenic lipid parameters in people with normal glucose tolerance: implications from elevated 1-hour post-load plasma glucose. Cardiovasc Diabetol. Published 14 May 2025. doi:10.
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