Lipids & metabolic liver disease
The association between different insulin resistance surrogates and all-cause mortality and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease
Authors' conclusion
Our findings highlight the prognostic value of IR indices, particularly TyG-BMI index, in predicting all-cause mortality and CVD mortality in MASLD patients.
Study context
- Population
- Adults aged ≥20 years with MASLD, National Health and Nutrition Examination Survey (NHANES) 2003–2018
- Participants
- 8,753 adults
- Exposure
- Quartiles of insulin resistance (IR) surrogates
- Outcome
- All-cause mortality and CVD mortality
- Follow-up
- Median 98 months
Methodological detailsNHANES 2003-2018, linked to National Death Index, quartile analysis, fully adjusted Cox proportional hazards models
- NHANES 2003-2018
- Linked to National Death Index
- Quartile analysis
- Fully adjusted Cox proportional hazards models
Main finding
As reported in the abstract
Deaths
1,234
Cardiovascular disease (CVD)-related deaths
409
TyG-body mass index (TyG-BMI) and all-cause mortality, HR
2.84 (1.73-4.67), P < 0.001 (95% CI)
TyG-BMI and CVD mortality, HR
5.32 (2.26-12.49), P < 0.001 (95% CI)
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline (RCS)) of TyG-BMI and mortality
- U-shaped relationship; threshold value
- 270.49
Subgroups
- Triglyceride-glucose (TyG)-related indices had stronger associations with mortality in elderly MASLD patients
Original publication
The association between different insulin resistance surrogates and all-cause mortality and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease. Cardiovasc Diabetol. Published 9 May 2025. doi:10.
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