Associations of Dietary Cholesterol Consumption With Incident Diabetes and Cardiovascular Disease: The Role of Genetic Variability in Cholesterol Absorption and Disease Predisposition
Authors' conclusion
DC consumption was not associated with incident diabetes and CVD, after adjusting for BMI, in the overall sample and in subgroups stratified by genetic predisposition to cholesterol absorption and the diseases. Nevertheless, whether genetic predisposition to cholesterol absorption modifies the DC-CVD association requires further investigation.
Study context
- Population
- UK Biobank participants with DC consumption assessed by repeated 24-h dietary recalls; incident diabetes and cardiovascular disease (CVD) analysesincident diabetes 96,826 · CVD 94,536
- Exposure
- Each additional 300 mg/day dietary cholesterol consumption
- Outcome
- Incident diabetes and CVD
Methodological detailsUK Biobank, polygenic risk score subgroup analysis, adjusted Cox models
- UK Biobank
- Polygenic risk score subgroup analysis
- Adjusted Cox models
Main finding
As reported in the abstract
Incident diabetes, HR
1.17 (1.07-1.27) (95% CI)
Incident CVD, HR
1.09 (1.03-1.17) (95% CI)
Incident diabetes, further adjusted for BMI, HR
0.99 (0.90-1.09) (95% CI)
Incident CVD, further adjusted for BMI, HR
1.04 (0.98-1.12) (95% CI)
Observational data: associations, not effects.
Further findings
Modification by genetic susceptibility to diabetes, coronary artery disease, stroke
- Genetic susceptibility to the diseases did not modify these associations
- P for interaction ≥ 0.06
DC-CVD association by non-HDL cholesterol-related polygenetic risk score (PRS) for cholesterol absorption
- Association appeared stronger with greater genetic susceptibility to cholesterol absorption; stratum-level estimates not statistically significant
- P for interaction = 0.04
Original publication
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