Dietary glycocalyx mimetic reduces vascular risk in Type 2 diabetes: evidence from urinary peptidomic classifiers in a South–Asian Surinamese Cohort
Primary result · HF2 urinary peptidomic classifier score (change from baseline)Result — go to the resultMean Δ −0.58 95 % CI −0.83 to −0.33Authors' conclusion
In this cohort, glycocalyx-mimetic supplementation improved the urinary peptidomic signature associated with heart-failure risk, whereas an FMD did not. Urinary peptidomics offers a sensitive molecular method for monitoring the effects of (dietary) interventions.
Study context
- Population
- South-Asian Surinamese adults with T2D
- Participants
- 44 adults
- Comparison
- Glycocalyx-mimetic supplement vs placebo vs fasting-mimicking diet
- Glycocalyx-mimeticn = 18
- Placebon = 14reference
- Fasting-mimicking diet (FMD)n = 12
Methodological detailsplacebo-controlled, three-arm, follow-up of a prior placebo-controlled trial
- Placebo-controlled
- Three-arm
- Follow-up of a prior placebo-controlled trial
Primary result
As reported in the abstract
Heart failure (HF2) urinary peptidomic classifier score (change from baseline) · week 12
Mean Δ
−0.58
95 % CI −0.83 to −0.33
adjusted p < 0.001
Glycocalyx-mimeticvs Placebo
mean Δ −0.58 (95 % CI −0.83 to −0.33); adjusted p < 0.001
Further findings
Coronary artery disease (CAD160) and chronic kidney disease (CKD273) risk scores · week 12
- CAD160 and CKD273 risk scores remained unchanged with glycocalyx-mimetic
Peptide-level changes · week 12
- Glycocalyx-mimetic altered the abundance of peptides, primarily decreasing collagen-derived fragments
- 17 peptides
Original publication
Dietary glycocalyx mimetic reduces vascular risk in Type 2 diabetes: evidence from urinary peptidomic classifiers in a South–Asian Surinamese Cohort. Diabetes Res Clin Pract. Published 4 October 2025. doi:10.
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