Lipids & metabolic liver disease
Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank
Authors' conclusion
This study demonstrateed the prognostic value of TyG-related indices in individuals with AF and MetS. These indices may serve as practical surrogate markers for risk stratification and the prevention of adverse outcomes.
Study context
- Population
- Participants with both atrial fibrillation (AF) and metabolic syndrome, UK Biobank
- Participants
- 2,535 participants
- Exposure
- Highest vs second quartile of triglyceride-glucose (TyG)-related indices
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Mean 12.7 years (IQR: 11.8-15.2)
Methodological detailsUK Biobank, Cox proportional hazards models, restricted cubic spline analyses
- UK Biobank
- Cox proportional hazards models
- Restricted cubic spline analyses
Main finding
As reported in the abstract
All-cause mortality · mean follow-up 12.7 years
Each group vs second quartileEstimate (95% CI)
Highest quartile
HR (TyG) 1.36(1.14–1.64)
Highest quartile
HR (TyG-BMI) 1.31(1.10–1.56)
Highest quartile
HR (TyG-WC) 1.41(1.18–1.68)
- Highest quartile
- HR (TyG-WHtR) 1.56 (95% CI 1.3--1.86)
- All-cause deaths
- 956
- Highest incidence of all-cause mortality in the fourth quartile of TyG (Kaplan-Meier, log-rank)
- log-rank P < 0.001
Observational data: associations, not effects.
Further findings
Cardiovascular mortality · mean follow-up 12.7 years
- Cardiovascular deaths
- 385
- TyG: HR
- 1.47 (1.10-1.95) (95% CI)
- TyG-WC: HR
- 1.41 (1.03-1.93) (CI)
- TyG-WHtR: HR
- 1.35 (1.01-1.80) (CI)
- Text names TyG, TyG-BMI and TyG-WHtR as significant, but the printed estimates are labelled TyG, TyG-WC and TyG-WHtR
Restricted cubic spline (RCS): nonlinear association between TyG and mortality and between TyG-BMI and all-cause mortality
- Nonlinear associations (all)
- P < 0.05
Sensitivity and subgroup analyses
- Consistent with the primary analyses
Original publication
Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank. Cardiovasc Diabetol. Published 29 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →