Lipids & metabolic liver disease
Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies
Authors' conclusion
Greater daytime light exposure, reduced nocturnal light exposure, and regulated RARs may protect against MASLD and prevent its progression to liver fibrosis and advanced liver disease.
Study context
- Population
- Participants of National Health and Nutrition Examination Survey (NHANES) and UK Biobank with accelerometry data
- Exposure
- Light exposure and 24-h rest-activity rhythm metrics vs MASLD risk
- Outcome
- Incident MASLD
Methodological details2 nationwide cohorts (NHANES and UK Biobank), accelerometry
- 2 nationwide cohorts (NHANES and UK Biobank)
- Accelerometry
Main finding
As reported in the abstract
MASLD risk (UK Biobank prospective analysis)
- Each 0.1-unit increase in relative amplitude (RA): MASLD risk reduction
- 30%
- Each 1-unit increase in M10: MASLD risk reduction
- 2%
- Each 1-unit increase in L5: MASLD risk increase
- 8%
- Delayed L5 onset: MASLD risk increase
- 21%
- Each additional hour of daylight exposure >6000 lux: lower MASLD risk
- 9%
- Each additional 30 min of nocturnal light exposure >30 lux: higher MASLD risk
- 22%
Observational data: associations, not effects.
Secondary outcomes
Fibrosis, cirrhosis and life expectancy among participants with MASLD
- Favorable 24 h-RAR profile and adequate light exposure associated with lower risk of fibrosis and cirrhosis and improved life expectancy
NHANES analysis
- Similar associations observed
Original publication
Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies. J Clin Endocrinol Metab. Published 29 October 2025. doi:10.
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