Association of genetic and epigenetic changes of insulin like growth factor binding protein-1 in Egyptian patients with type 2 diabetes mellitus
Authors' conclusion
We concluded that DNA hyper methylation of IGFBP-1 gene and CC polymorphism (rs 2854843) of IGFBP-1 gene are associated with T2DM in Egyptian patients, also, decrease serum level of IGFBP-1. Further cohort study is recommended with large sample size to detect which one, epigenetic changes or polymorphism of IGFBP-1 gene, is the cause of T2DM or even both.
Study context
- Population
- Egyptian patients with T2D and controls
- Participants
- 100 vs 100
- Comparison
- T2D vs control
- T2DMn = 100
- Controln = 100reference
- Outcome
- IGFBP-1 gene methylation, polymorphism and serum IGFBP-1
Methodological detailsDNA methylation by pyrosequencing; polymorphism by real time PCR; serum IGFBP-1 by ELISA
- DNA methylation by pyrosequencing; polymorphism by real time PCR; serum IGFBP-1 by ELISA
Main finding
As reported in the abstract
- T2DM vs Control: P < 0.001
- T2DM vs Control: P = 0.002
- T2DM vs Control: P < 0.001
Observational data: associations, not effects.
Original publication
Association of genetic and epigenetic changes of insulin like growth factor binding protein-1 in Egyptian patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 22 April 2023. doi:10.
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