Sleep Patterns, Plasma Metabolome, and Risk of Incident Type 2 Diabetes Mellitus
Main finding · Incident T2D (1489 cases)Result — go to the resultMultivariable-adjusted HR 0.51 95% CI 0.40–0.63Authors' conclusion
In this large prospective study, we identified a metabolomic signature for the healthy sleep pattern, and such a signature showed a potential causality with T2DM risk independent of traditional risk factors.
Study context
- Population
- UK Biobank participants with complete sleep information and metabolomic measurementsUK Biobank
- Participants
- 78,659 participants
- Exposure
- Healthy vs unhealthy sleep pattern; metabolomic signature of sleep pattern and T2D risk
- Outcome
- Incident T2D
- Follow-up
- Median 8.8 years
Methodological detailsmetabolomic signature by elastic net regularized regression, genome-wide association analysis, one-sample mendelian randomization
- Metabolomic signature by elastic net regularized regression
- Genome-wide association analysis
- One-sample mendelian randomization
Main finding
Incident T2D (1489 cases) · median 8.8 years
Multivariable-adjusted HR
0.51
95% CI 0.40–0.63
Healthy sleep patternvs Unhealthy sleep pattern
multivariable-adjusted HR 0.51 (95% CI 0.40–0.63)
As reported in the abstract
- Metabolomic signature (153 metabolites) and T2D risk, HR per SD increment (95% CI 0.52-0.60), multivariable Cox
- 0.56
Observational data: associations, not effects.
Original publication
Sleep Patterns, Plasma Metabolome, and Risk of Incident Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. Published 21 April 2023. doi:10.
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