Associations of Slow-Wave Sleep With Prevalent and Incident Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis
Authors' conclusion
Higher N3 proportion and longer N3 duration were prospectively associated with lower type 2 diabetes risk in a nonlinear fashion among older American adults.
Study context
- Population
- MESA participants with polysomnography at Exam 5 (2010–2013), followed until Exam 6 (2016–2018); mean age 69 years1,251 in prospective analyses
- Participants
- 2,026 participants
- Exposure
- Quartiles of N3 sleep proportion
- Outcome
- Prevalent and incident T2D
Methodological detailscross-sectional and prospective analyses of the Multi-Ethnic Study of Atherosclerosis, 1-night polysomnography, modified Poisson regression, Cox proportional hazards models
- Cross-sectional and prospective analyses of the Multi-Ethnic Study of Atherosclerosis
- 1-night polysomnography
- Modified Poisson regression
- Cox proportional hazards models
Main finding
As reported in the abstract
Incident diabetes (fully adjusted) · 6346 person-years of follow-up
Each group vs Q1Hazard ratio (95% CI)P value
Q2
0.47(0.26–0.87)
Q3
0.34(0.15–0.77)
Q4
0.32(0.10–0.97)
P nonlinearity = .0213- Incident cases
- 129
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Prevalent diabetes (cross-sectional)Q4 vs Q1 | (95% CI 0.58–0.87) | P for trend = 0.0016 |
- Prevalent diabetes (cross-sectional) — Diabetes prevalence
- 28% (n = 572)
- Prevalent diabetes (cross-sectional) — Attenuated after adjustment for demographics, lifestyles, and sleep-related factors
- P trend = .3322
Original publication
Associations of Slow-Wave Sleep With Prevalent and Incident Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis. J Clin Endocrinol Metab. Published 21 April 2023. doi:10.
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