Association between the systemic immune-inflammation index and metabolic syndrome and its components: results from the multi-ethnic study of atherosclerosis (MESA)
Authors' conclusion
Higher SII scores were associated with an increased likelihood of MetS, hyperglycemia, and high BP among middle-aged and older adults. Longitudinal studies are needed to determine the causal relationships between SII and the development of MetS, as well as to assess the potential role of SII as a screening tool in clinical practice.
Study context
- Population
- Middle-aged and older adults aged 45–84 years, MESA cohort (1305 men)1,082 with metabolic syndrome (MetS)
- Participants
- 2,755 participants
- Exposure
- SII and MetS and its components
- Outcome
- MetS and its components
Methodological detailsMESA cohort, examination 5 (2010-2012), logistic regression
- MESA cohort, examination 5 (2010-2012)
- Logistic regression
Main finding
As reported in the abstract
MetS, OR per SII (continuous)
1.23
95% CI 1.05–1.46
Hyperglycemia, OR per SII (continuous) (1.05-1.44)
1.23
Elevated blood pressure (BP), OR per SII (continuous) (1.14-1.89)
1.47
Observational data: associations, not effects.
Further findings
SII quartile 4 vs quartile 1
- Higher prevalence of hyperglycemia, Q4 vs Q1 (P for trend: 0.021)
- 32%
- Higher prevalence of elevated BP, Q4 vs Q1 (P for trend: < 0.001)
- 63%
Low HDL-C, SII quartile 2 vs quartile 1
- OR Q2 vs Q1 (1.07-1.83), P trend = 0.454
- 1.40
Abdominal obesity by general obesity status (subgroup analysis)
- Obese: OR (1.00-2.95)
- 1.72
- Non-obese: OR (0.66-0.97)
- 0.80
- P for interaction
- 0.009
Original publication
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