Prediabetes and sleep patterns: Linking poor sleep to adverse outcomes through metabolic syndrome
Authors' conclusion
In adults with prediabetes, both poor and intermediate sleep patterns are associated with an increased risk of adverse outcomes. Metabolic syndrome partially mediates the relationship between sleep patterns and adverse outcomes.
Study context
- Population
- Adults with prediabetes, UK Biobank; sleep pattern of five sleep factors
- Participants
- 44,938 adults
- Exposure
- Intermediate and poor sleep patterns vs healthy sleep pattern
- Outcome
- Risk of adverse health outcomes
Methodological detailsmediation analysis
- Mediation analysis
Main finding
As reported in the abstract
Adverse outcomes
Hazard ratio
1.07 to 1.31
Intermediate sleep pattern
Hazard ratio
1.21 to 1.92
Poor sleep pattern
- Risk increase per each poor sleep factor increase
- 4% to 23%
Observational data: associations, not effects.
Further findings
- Mediation proportions (metabolic syndrome may partially mediate)
- 0.94% to 9.61%
Original publication
Prediabetes and sleep patterns: Linking poor sleep to adverse outcomes through metabolic syndrome. Diabetes Res Clin Pract. Published 14 February 2025. doi:10.
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