Association of Resting Heart Rate Trajectories With Cardiovascular Disease and Mortality in Patients With Diabetes Mellitus
Authors' conclusion
RHR trajectories were associated with the subsequent risks of CVD and all-cause mortality in patients with diabetes mellitus.
Study context
- Population
- Participants with DM in the Kailuan Study (general community) who attended ≥3 of the 2006, 2008, 2010 and 2012 examinations
- Participants
- 8,218 participants
- Exposure
- Resting heart rate (RHR) trajectories vs low-stable
- Low-stablen = 1,705reference
- Moderate-stablen = 5,437
- High-decreasingn = 862
- High-increasingn = 214
- Outcome
- CVD and all-cause mortality
- Follow-up
- Average 7.25 years
Methodological detailscommunity-based, biennial health examinations, Health examinations biennially from 2006; follow-up until December 31, 2020
- Community-based
- Biennial health examinations
- Health examinations biennially from 2006; follow-up until December 31, 2020
Main finding
As reported in the abstract
Each group vs low-stableEstimate (95% CI)P value
High-increasing
adjusted HR for CVD 1.48(1.02–2.14)
P = 0.04Moderate-stable
adjusted HR for all-cause mortality 1.34(1.14–1.58)
P < 0.01High-decreasing
adjusted HR for all-cause mortality 1.68(1.35–2.10)
P < 0.01High-increasing
adjusted HR for all-cause mortality 2.47(1.85–3.31)
P < 0.01- Cardiovascular disease (CVD) cases
- 977
- Deaths
- 1162
Observational data: associations, not effects.
Original publication
Association of Resting Heart Rate Trajectories With Cardiovascular Disease and Mortality in Patients With Diabetes Mellitus. J Clin Endocrinol Metab. Published 21 April 2023. doi:10.
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