Association of Bone Mineral Density and Bone Turnover Markers with the Risk of Diabetes: Hong Kong Osteoporosis Study and Mendelian Randomization
Authors' conclusion
Higher BMD and lower levels of circulating bone biomarkers were cross-sectionally associated with poor glycemic control. Moreover, higher BMD was associated with a higher risk of incident T2DM and the association is probably causal.
Study context
- Population
- Participants of the Hong Kong Osteoporosis Study (HKOS)prospective
- Participants
- 7,160 participants
- Exposure
- Higher vs lower BMD and bone turnover markers
- Outcome
- Incident T2DM by BMD at study sites
- Follow-up
- Median 16.8 years
Methodological detailsBody mass index (BMI)-adjusted full models
- BMI-adjusted full models
Main finding
As reported in the abstract
Incident T2DM per 0.1 g/cm² higher BMD · median 16.8 years
Femoral neck BMD (0.1 g/cm²), HR
1.10 (1.03 to 1.18) (95% CI)
Total hip BMD (0.1 g/cm²), HR
1.14 (1.08 to 1.21) (95% CI)
Osteoporosis vs normal BMD, HR (95% CI); 30% risk reduction
0.70
0.55 to 0.90
Observational data: associations, not effects.
Further findings
Cross-sectional: fasting glucose and HbA1c
- Lower circulating bone turnover markers and higher BMD significantly associated with increased fasting glucose and HbA1c
Mendelian randomization (MR): genetically estimated BMD (eBMD)
- eBMD and 2-h glucose after oral glucose challenge, estimate
- 0.043 (0.007 to 0.079) (95% CI)
- eBMD and T2DM, OR
- 1.064 (1.036 to 1.093) (95% CI)
Original publication
Association of Bone Mineral Density and Bone Turnover Markers with the Risk of Diabetes: Hong Kong Osteoporosis Study and Mendelian Randomization. J Bone Miner Res. Published 14 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →